治療用のafucosylated mAbs
2018年現在で、3つのafucosylated mAbsが市場に、20以上が臨床試験にあります。
| name and company | Target andformat | comment |
| obinutuzumab/GA101/Gazyva Roche | CD20 Humanized IgG1 with low fucose content | Marketed first glycoengineered therapeutic anti-CD20, in 2013 by FDA 3 x Phase 1~3 |
| mogamulizumab/POTELIGEO/KM0761 Kyowa Hakko Kirin | CD chemokine receptor 4(CCR4) Humanized afucosylated IgG1 | Marketed in lymphoma first approved in 2013 in Japan for hematologic malignancies in 2014 for cutneous T-cell lymphoma (CTCL) in 2017, FDA granted itbreakthrough, FUT8-knockout CHO 10 x Phase1~3 |
| Benralizumab/MDEI-563/Fasenra AstraZeneca | IL-5Rα Humanized afucosylated IgG1 | Marketed in Asthma approved by FDA in 2017 for severe eosinophil asthma, FUT8-knockout CHO (Biowa Poteligent Technology), IL-5R 9 x Phase1~3 |
| Inebilizumab/MEDI-551 Medlmmune | CD19 Humanized afucosylated IgG1 | 10 x Phase1,2 and 3 (lymphoma,myeloma) |
| Ublituximab/TG1101/LFB-R603 TG Therapeutics Inc | CD20 Chimeric IgG1, low fucose content | 10 x Phase 1,2 and 3 in lymphoma, leukemia |
| TrasGEX/GT-MAB7.3-GEX/Glycooptimized Trastuzumab-GEX | HER2 Mumanized glyco-optimized (reduced fucosylated IgG1) | Solid Tumors in Phase 1 (completed) |
| SEA-CD40/Seattle Genetics | humanized afucosylated anti-CD40 IgG1 | Cancer and carcinomas in Phase 1 |
以上
参考文献
1)
The “less-is-more” in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity, 2018
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150623/
2)
Glycosilation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777974/#!po=7.60870
3)
Improved in vitro and in vivo activity against CD303-expressing targets of the chimeric 122A2 antibody selected for specific glycosylation pattern, 2018
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973763/
4)
細胞性免疫・エフェクター細胞 – 日本ガン免疫学会
http://jaci.jp/patient/immune-cell/immune-cell-04/
5)
対立遺伝子
https://mycode.jp/glossary/allele.html
編集履歴
2020/02/22, by S2IND